Endocrine Abstracts

Case history: A 54-year-old man was admitted with a history of syncopal episodes. Orthostatic hypotension led to an endocrine referral and subsequent diagnosis of pan-anterior hypopituitarism but with no evidence of posterior pituitary involvement. Although an initial aetiological diagnosis remained elusive, further work-up (see below) led to a histology-confirmed diagnosis of ACE-negative neurosarcoidosis. This diagnostic conundrum could have been contributed by a prior neuro...

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is regarded as a precursor to the development of carcinoid tumorlets. It is confined to the neuroendocrine cell of the airway mucosa without penetration through the basement membrane and appears in a diffuse pattern, typically in association with obliterative bronchiolar fibrosis. DIPNECH belongs to the preinvasive lesions defined by the 1999 World Health Organization classification, along with atypical ade...